ABSTRACT
The theoretical origin of the combined therapy of lung and intestine can be traced back to the Inner Canon of Huangdi, which explains the physiological and pathological interaction between the lung and the large intestine. In recent years, researchers have investigated the scientific essence of the "lung- intestine axis" theory from many aspects, which enriches the relevant theoretical basis, and applied it to the treatment of COVID-19, acute lung injury, and other lung diseases. The close relation between lung and intestine in many aspects embodies the holistic conception of traditional Chinese medicine and explains the holistic theory of interrelation between organs, which correlate to each other physiologically and pathologically. Intestinal microecological disorders can affect lung immune function and cause respiratory diseases, and respiratory diseases are usually accompanied by gastrointestinal symptoms. Lung diseases can be prevented and treated by regulating intestinal flora. According to histoembryology, the epithelial tissue of the lung and intestine comes from primitive foregut. In immunology, both lung and intestine contain mucosa-associated lymphoid tissue, and the pathological changes of the respiratory tract are also closely related to intestinal microorganisms. The tissue origin of lung and large intestine, the correlation of mucosal immunity, and the synchronization of ecological changes provide a scientific basis for the combined therapy of lung and intestine. Therefore, this paper summarizes the theoretical origin, modern research mechanism, and clinical application of combined therapy of lung and intestine, in order to provide a new direction for its application in clinical and scientific research.Copyright © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.
ABSTRACT
BACKGROUND: Our aim was to estimate provisional willingness to receive a coronavirus 2019 (COVID-19) vaccine, identify predictive socio-demographic factors, and, principally, determine potential causes in order to guide information provision. METHODS: A non-probability online survey was conducted (24th September-17th October 2020) with 5,114 UK adults, quota sampled to match the population for age, gender, ethnicity, income, and region. The Oxford COVID-19 vaccine hesitancy scale assessed intent to take an approved vaccine. Structural equation modelling estimated explanatory factor relationships. RESULTS: 71.7% (n=3,667) were willing to be vaccinated, 16.6% (n=849) were very unsure, and 11.7% (n=598) were strongly hesitant. An excellent model fit (RMSEA=0.05/CFI=0.97/TLI=0.97), explaining 86% of variance in hesitancy, was provided by beliefs about the collective importance, efficacy, side-effects, and speed of development of a COVID-19 vaccine. A second model, with reasonable fit (RMSEA=0.03/CFI=0.93/TLI=0.92), explaining 32% of variance, highlighted two higher-order explanatory factors: 'excessive mistrust' (r=0.51), including conspiracy beliefs, negative views of doctors, and need for chaos, and 'positive healthcare experiences' (r=-0.48), including supportive doctor interactions and good NHS care. Hesitancy was associated with younger age, female gender, lower income, and ethnicity, but socio-demographic information explained little variance (9.8%). Hesitancy was associated with lower adherence to social distancing guidelines. CONCLUSIONS: COVID-19 vaccine hesitancy is relatively evenly spread across the population. Willingness to take a vaccine is closely bound to recognition of the collective importance. Vaccine public information that highlights prosocial benefits may be especially effective. Factors such as conspiracy beliefs that foster mistrust and erode social cohesion will lower vaccine up-take.
ABSTRACT
COVID-19 cripples the restaurant industry as a crucial socioeconomic sector that contributes immensely to the global economy. However, what the current literature less explored is to quantify the effect of COVID-19 on restaurant visitation and revenue at different spatial scales, as well as its relationship with the neighborhood characteristics of customers' origins. Based on the Point of Interest (POI) measures derived from SafeGraph data providing mobility records of 45 million cell phone users in the US, our study takes Lower Manhattan, New York City, as the pilot study, and aims to examine 1) the change of restaurant visitations and revenue in the period prior to and after the COVID-19 outbreak, 2) the areas where restaurant customers live, and 3) the association between the neighborhood characteristics of these areas and lost customers. By doing so, we provide a geographic information system-based analytical framework integrating the big data mining, web crawling techniques, and spatial-economic modelling. Our analytical framework can be implemented to estimate the broader effect of COVID-19 on other industries and can be augmented in a financially monitoring manner in response to future pandemics or public emergencies.
ABSTRACT
Confronting the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), simple, fast and specific non-laboratory SARS-CoV-2 diagnostic tests are urgently required. However, the current nucleic acid assays generally rely on the diagnostic laboratory, trained staff and specialized equipment for execution and analysis, presenting clear limitations in the field detection. Here, we describe a portable and reliable immobilization-based loop-mediated isothermal amplification (LAMP) device which is mobile, without the requirement of any complicated instrument and appropriate for high-throughput testing. This device was constructed by utilizing the interaction between a carboxyl-tagged primer and an amino-tagged substrate, and capable of catching the target sequence in SARS-CoV-2 produced via the immobilization-based LAMP. In this study, the immobilization conditions and immobilized primer structure were explored and optimized. With this proposed device, the analysis result can be obtained rapidly in 30 min with excellent specificity, even if the template is extracted from a complex sample containing pharyngeal swab or human blood. In addition, the device can be applied to detect the nucleic acid of SARS-CoV-2 and various other pathogens, showing attractive potential for rapid and high-throughput detection at airports, railway stations, cold-chain transportations, community hospitals and so on. Therefore, we believe that the immobilization-based LAMP device is an advanced approach to developing a portable, specific, low-cost and high-throughput diagnostic platform.
ABSTRACT
The theoretical origin of the combined therapy of lung and intestine can be traced back to the Inner Canon of Huangdi, which explains the physiological and pathological interaction between the lung and the large intestine. In recent years, researchers have investigated the scientific essence of the "lung- intestine axis" theory from many aspects, which enriches the relevant theoretical basis, and applied it to the treatment of COVID-19, acute lung injury, and other lung diseases. The close relation between lung and intestine in many aspects embodies the holistic conception of traditional Chinese medicine and explains the holistic theory of interrelation between organs, which correlate to each other physiologically and pathologically. Intestinal microecological disorders can affect lung immune function and cause respiratory diseases, and respiratory diseases are usually accompanied by gastrointestinal symptoms. Lung diseases can be prevented and treated by regulating intestinal flora. According to histoembryology, the epithelial tissue of the lung and intestine comes from primitive foregut. In immunology, both lung and intestine contain mucosa-associated lymphoid tissue, and the pathological changes of the respiratory tract are also closely related to intestinal microorganisms. The tissue origin of lung and large intestine, the correlation of mucosal immunity, and the synchronization of ecological changes provide a scientific basis for the combined therapy of lung and intestine. Therefore, this paper summarizes the theoretical origin, modern research mechanism, and clinical application of combined therapy of lung and intestine, in order to provide a new direction for its application in clinical and scientific research. © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.
ABSTRACT
Along with the continuous outbreak of COVID-19, countries all over the world have taken measures to prevent and control the virus, moreover, the pandemic measures taken in the communities are the most strict ones in particular. Currently, the health data of residents is collected manually in most communities when the pandemic is stable to some extent. Then, the pandemic risks confronted by residents are assessed accordingly, however, only the minority of communities verify the health identities of residents by scanning their health code. In such a background, the completed and humanized platform systems have not yet been designed and promoted in the market for further pandemic prevention and control. This system distinguishes the administrator from the user, the user homepage mainly has the function of viewing the announcement, the problem feedback, the membership application, the volunteer service and so on. The administrator homepage has the functions of registered user management, isolation audit management, volunteer service management, access management and so on. In addition, based on the fundamental pandemic prevention measures, the system is also endowed with function as big data analysis, which can analyze the epidemic data of inland provinces in China at the present stage to further strengthen epidemic prevention and control. Prevent infected people from entering the community and form a large-scale infection. © 2021 IEEE.
ABSTRACT
medical service robot, human-robot interaction, COVID-19, sensor fusion The cabin hospitals used for COVID-19 victims have an infectious environment and thus require highly autonomous systems to provide various services. This article presents a multirobot architecture designed for cabin hospitals with special focus on the sensors used by service robots. The robots' functions include autonomous disinfection, delivery, cleaning, temperature measurement, physical interaction, and conversation assistance. The robots collaborate with each other by using multiple sensors in large and complicated scenes and evolve together. The robots are controlled by cloud controllers considering a human-centered multi-robot collaboration mechanism. This article presents the details of these robots, including the hardware and software architecture of the robots with sensors, the communication modules, and the cloudbased central controllers. It also presents several applications of the robots and discusses open problems. © 2021 M Y U Scientific Publishing Division. All rights reserved.
ABSTRACT
We explore the implications of online social endorsement for the Covid-19 vaccination program in the United Kingdom. Vaccine hesitancy is a long-standing problem, but it has assumed great urgency due to the pandemic. By early 2021, the United Kingdom had the world?s highest Covid-19 mortality per million of population. Our survey of a nationally representative sample of UK adults (N?=?5,114) measured socio-demographics, social and political attitudes, media diet for getting news about Covid-19, and intention to use social media and personal messaging apps to encourage or discourage vaccination against Covid-19. Cluster analysis identified six distinct media diet groups: news avoiders, mainstream/official news samplers, super seekers, omnivores, the social media dependent, and the TV dependent. We assessed whether these media diets, together with key attitudes, including Covid-19 vaccine hesitancy, conspiracy mentality, and the news-finds-me attitude (meaning giving less priority to active monitoring of news and relying more on one?s online networks of friends for information), predict the intention to encourage or discourage vaccination. Overall, super-seeker and omnivorous media diets are more likely than other media diets to be associated with the online encouragement of vaccination. Combinations of (a) news avoidance and high levels of the news-finds-me attitude and (b) social media dependence and high levels of conspiracy mentality are most likely to be associated with online discouragement of vaccination. In the direct statistical model, a TV-dependent media diet is more likely to be associated with online discouragement of vaccination, but the moderation model shows that a TV-dependent diet most strongly attenuates the relationship between vaccine hesitancy and discouraging vaccination. Our findings support public health communication based on four main methods. First, direct contact, through the post, workplace, or community structures, and through phone counseling via local health services, could reach the news avoiders. Second, TV public information advertisements should point to authoritative information sources, such as National Health Service (NHS) and other public health websites, which should then feature clear and simple ways for people to share material among their online social networks. Third, informative social media campaigns will provide super seekers with good resources to share, while also encouraging the social media dependent to browse away from social media platforms and visit reliable and authoritative online sources. Fourth, social media companies should expand and intensify their removal of vaccine disinformation and anti-vax accounts, and such efforts should be monitored by well-resourced, independent organizations.
ABSTRACT
A worldwide pandemic has brought many challenges in numerous areas of everyone's life. The AutomotiveUI 2020 has also been moved to a virtual conference. Although the situation seems to be improving in some parts of the world, the impacts that the pandemic has brought to the research and academia may last long even after the pandemic is over. In the AutomotiveUI community, there is more than one aspect that should be taken into consideration. Ironically, the situation brought about both risks and opportunities including research methods, collaboration, interaction manners, and diversity and inclusion. With this background, the goal of this workshop is to discuss the impact of the COVID19 pandemic on the AutomotiveUI community from the perspective of the diversity and inclusion and to discuss the direction of collaborative activities of our community with researchers from various groups. We will organize three virtual workshop sessions accomodating different time zones. © 2020 Owner/Author.